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ADD: 2020-10-11T21:41:43
Characterization of Therapeutic Antibodies and Related Products. ACS Med. Both Bodipy probes also potently inhibit UCHL1 in a cell lysate, although to a somewhat lesser extent, which could be expected on the basis of their IC 50 values. Consistent with USP7 target engagement in cells, FT destabilizes USP7 substrates including MDM2, increases levels of p53, and results in the transcription of p53 target genes, induction of the tumor suppressor p21, and inhibition of tumor growth in mice. Importantly, no significant decrease in the 8RK59 signal was detected in the PARK7 knockdown zebrafish embryos based on the fluorescence imaging and signal analysis results of 4 dpf embryos Supporting Information Figure S6E,F. We find that the cellular abundance of proteins is predominantly controlled at the level of translation. Each well had a final volume of

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